Sociosexual and Communication Deficits after Traumatic Injury to the Developing Murine Brain
Bridgette D Semple, Linda J Noble-Haeusslein, Yong Jun Kwon, Pingdewinde N Sam, A Matt Gibson, Sarah Grissom, Sienna Brown, Zahra Adahman, Christopher A Hollingsworth, Alexander Kwakye, Kayleen Gimlin, Elisabeth A Wilde, Gerri Hanten, Harvey S Levin, A Katrin Schenk
PLOS ONE | PUBLIC LIBRARY SCIENCE | Published : 2014
Despite the life-long implications of social and communication dysfunction after pediatric traumatic brain injury, there is a poor understanding of these deficits in terms of their developmental trajectory and underlying mechanisms. In a well-characterized murine model of pediatric brain injury, we recently demonstrated that pronounced deficits in social interactions emerge across maturation to adulthood after injury at postnatal day (p) 21, approximating a toddler-aged child. Extending these findings, we here hypothesized that these social deficits are dependent upon brain maturation at the time of injury, and coincide with abnormal sociosexual behaviors and communication. Age-dependent vul..View full abstract
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Awarded by National Institutes of Health/National Institute of Neurological Disorders and Stroke
Awarded by National Health and Medical Research Council of Australia
Awarded by Division Of Human Resource Development
Awarded by NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
Awarded by NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
Funding was provided by National Institutes of Health/National Institute of Neurological Disorders and Stroke (http://www.ninds.nih.gov/), R01 #NS050159 and #NS077767 (awarded to LJNH), a CJ Martin Overseas Biomedical Postdoctoral Fellowship from the National Health and Medical Research Council of Australia (https://www.nhmrc.gov.au/) #1052505(awarded to BDS), and Randolph College start-up funds (AKS). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.