Journal article

Determinant spreading: lessons from animal models and human disease

J McCluskey, AD Farris, CL Keech, AW Purcell, M Rischmueller, G Kinoshita, P Reynolds, TP Gordon

IMMUNOLOGICAL REVIEWS | MUNKSGAARD INT PUBL LTD | Published : 1998

Abstract

Spreading of the immune response is a common theme in organ-specific and systemic autoimmune diseases. We evaluated whether some of the mixed antinuclear antibody patterns characteristic of systemic autoimmunity might be the result of determinant spreading from a single initiating event. Immunisation of healthy mice with individual protein components of the La/Ro ribonucleoprotein (RNP) targeted in systemic lupus erythematosus and primary Sjögren's syndrome induced autoantibodies recognising Ro60 (SS-A), Ro52 (SS-A) and La (SS-B) and in some cases the molecular chaperones calreticulin and Grp78. The endogenous antigen(s) driving determinant spreading might be derived from physiological apopt..

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University of Melbourne Researchers