Enteric neural progenitors are more efficient than brain-derived progenitors at generating neurons in the colon
Quan Findlay, Kiryu K Yap, Annette J Bergner, Heather M Young, Lincon A Stamp
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY | AMER PHYSIOLOGICAL SOC | Published : 2014
Gut motility disorders can result from an absent, damaged, or dysfunctional enteric nervous system (ENS). Cell therapy is an exciting prospect to treat these enteric neuropathies and restore gut motility. Previous studies have examined a variety of sources of stem/progenitor cells, but the ability of different sources of cells to generate enteric neurons has not been directly compared. It is important to identify the source of stem/progenitor cells that is best at colonizing the bowel and generating neurons following transplantation. The aim of this study was to compare the ability of central nervous system (CNS) progenitors and ENS progenitors to colonize the colon and differentiate into ne..View full abstract
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Awarded by National Health and Medical Research Council Australia
This work was supported by National Health and Medical Research Council Australia Project Grant No. 1019931.