Journal article
A pro-inflammatory role for Th22 cells in Helicobacter pylori-associated gastritis
Y Zhuang, P Cheng, XF Liu, LS Peng, BS Li, TT Wang, N Chen, WH Li, Y Shi, W Chen, KC Pang, M Zeng, XH Mao, SM Yang, H Guo, G Guo, T Liu, QF Zuo, HJ Yang, LY Yang Show all
Gut | Published : 2015
Open access
Abstract
Objective Helper T (Th) cell responses are critical for the pathogenesis of Helicobacter pylori-induced gastritis. Th22 cells represent a newly discovered Th cell subset, but their relevance to H. pylori-induced gastritis is unknown. Design Flow cytometry, real-time PCR and ELISA analyses were performed to examine cell, protein and transcript levels in gastric samples from patients and mice infected with H. pylori. Gastric tissues from interleukin (IL)-22-deficient and wild-type (control) mice were also examined. Tissue inflammation was determined for pro-inflammatory cell infiltration and proinflammatory protein production. Gastric epithelial cells and myeloid-derived suppressor cells (MDSC..
View full abstractGrants
Funding Acknowledgements
This work was supported by a grant of Medical Science Youth Training Project of Chinese People's Liberation Army (13QNP108), National Natural Science Foundation of China (31270174) and 81201265 and National Basic Research Program of China (973 Program, No. 2009CB522606).