New biomarkers for the prediction of spontaneous preterm labour in symptomatic pregnant women: a comparison with fetal fibronectin
S Liong, MKW Di Quinzio, G Fleming, M Permezel, GE Rice, HM Georgiou
BJOG An International Journal of Obstetrics & Gynaecology | WILEY-BLACKWELL | Published : 2015
OBJECTIVE: To identify cervicovaginal fluid (CVF) biomarkers predictive of spontaneous preterm birth in women with symptoms of preterm labour. DESIGN: Retrospective cohort study. SETTING: Melbourne, Australia. POPULATION: Women with a singleton pregnancy admitted to the Emergency Department between 22 and 36 weeks of gestation presenting with symptoms of preterm labour. METHODS: Two-dimensional electrophoresis was used to analyse the CVF proteome. Validation of putative biomarkers was performed using enzyme-linked immunosorbent assay (ELISA) in an independent cohort. Optimal concentration thresholds of putative biomarkers were determined and the predictive efficacy for preterm birth was comp..View full abstract
Funding was provided by the Medical Research Foundation for Women and Babies. SL is a recipient of an Australian Postgraduate Award (Australian Government Department of Industry).