Book Chapter

Cytotoxic granules house potent proapoptotic toxins critical for antiviral responses and immune homeostasis

K Baran, I Voskoboinik, NJ Waterhouse, VR Sutton, JA Trapani

Apoptosis: Physiology and Pathology | Published : 2011

Abstract

General Introduction Cytotoxic lymphocytes and apoptosis The immune system of high-order organisms is a highly specialized compartment that eliminates transformed cells and cells infected with viruses or bacteria through a controlled process of cell-mediated cytotoxicity. The immune cells responsible for mediating cell death are collectively called cytotoxic lymphocytes (CLs) and are made up of natural killer (NK) cells and cytotoxic T lymphocytes (CTL). CLs are distinguished primarily by their respective mechanism of antigen recognition. NK cells form part of the innate immune response, a generalized first line of defense. NK cells are generally CD3aeCD56+lymphocytes that recognize and resp..

View full abstract