Journal article
Effects of Tamoxifen and oestrogen on histology and radiographic density in high and low mammographic density human breast tissues maintained in murine tissue engineering chambers
GL Chew, CW Huo, D Huang, T Blick, P Hill, J Cawson, H Frazer, MC Southey, JL Hopper, K Britt, MA Henderson, I Haviv, EW Thompson
Breast Cancer Research and Treatment | SPRINGER | Published : 2014
Abstract
Mammographic density (MD) is a strong risk factor for breast cancer. It is altered by exogenous endocrine treatments, including hormone replacement therapy and Tamoxifen. Such agents also modify breast cancer (BC) risk. However, the biomolecular basis of how systemic endocrine therapy modifies MD and MD-associated BC risk is poorly understood. This study aims to determine whether our xenograft biochamber model can be used to study the effectiveness of therapies aimed at modulating MD, by examine the effects of Tamoxifen and oestrogen on histologic and radiographic changes in high and low MD tissues maintained within the biochamber model. High and low MD human tissues were precisely sampled u..
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Awarded by Macmillan Cancer Support
Funding Acknowledgements
This work was supported by the Victorian Breast Cancer Research Consortium (MCS, EWT, JH), the St Vincent's Hospital Research Endowment Fund (EWT 2008, 2009), the National Health and Medical Research Council (GLC, MCS, JH) and the University of Melbourne Research Grant Support Scheme (MRGSS; EWT, IH, GLC). This study benefited from support by the Victorian Government's Operational Infrastructure Support Program to St. Vincent's Institute.