A Vasoactive Role for Endogenous Relaxin in Mesenteric Arteries of Male Mice
Chen Huei Leo, Maria Jelinic, Jon H Gooi, Marianne Tare, Laura J Parry
PLOS ONE | PUBLIC LIBRARY SCIENCE | Published : 2014
The peptide hormone relaxin has striking effects on the vascular system. Specifically, endogenous relaxin treatment reduces myogenic reactivity through nitric oxide (NO)-mediated vasorelaxation and increases arterial compliance in small resistance arteries. However, less is known about the vascular roles of endogenous relaxin, particularly in males. Therefore, we used male wild-type (Rln+/+) and relaxin knockout (Rln-/-) mice to test the hypothesis that passive wall properties and vascular reactivity in mesenteric arteries would be compromised in Rln-/- mice. Passive compliance was determined in arteries (n=8-9) mounted on a pressure myograph and in Ca2+-free Krebs containing 2 mM EGTA. Pass..View full abstract
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Awarded by Australian Research Council
The research was funded by an Australian Research Council Linkage Grant (LP110200543) and an Australian and New Zealand Medical Research and Technology in Victoria Grant, with partial funding from Novartis Pharma AG. MJ received an Australian Postgraduate Award. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.