Journal article
An exploratory trial of basal and prandial insulin initiation and titration for type 2 diabetes in primary care with adjunct retrospective continuous glucose monitoring: INITIATION study
ID Blackberry, JS Furler, LE Ginnivan, JA Manski-Nankervis, A Jenkins, N Cohen, JD Best, D Young, D Liew, G Ward, DN O'Neal
Diabetes Research and Clinical Practice | Published : 2014
Abstract
Aims: To evaluate basal and prandial insulin initiation and titration in people with type 2 diabetes mellitus (T2DM) in primary care and to explore the feasibility of retrospective-continuous glucose monitoring (r-CGM) in guiding insulin dosing. The new model of care features General Practitioners (GPs) and Practice Nurses (PNs) working in an expanded role, with Credentialed Diabetes Educator - Registered Nurse (CDE-RN) support. Methods: Insulin-naïve T2DM patients (HbA1c >7.5% [>58. mmol/mol] despite maximal oral therapy) from 22 general practices in Victoria, Australia commenced insulin glargine, with glulisine added as required. Each was randomised to receive r-CGM or self-monitoring of b..
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Awarded by Medtronic
Funding Acknowledgements
The INITIATION study was an investigator initiated study. We gratefully acknowledge funding and material support by the Australian National Health and Medical Research Council (NHMRC), Centre of Clinical Research Excellence (CCRE) in Diabetes Science (ID 454461 CIA JD Best), Sanofi and Medtronic. The grant proposal was independently peer-reviewed by the NHMRC CCRE in Diabetes Science, Sanofi and Medtronic. JF is supported by an NHMRC-PHCRED Career Development Fellowship. Abbott donated the blood glucose meters (BGMs) and BD supplied the needle starter packs. We gratefully acknowledge the participation of the following primary care centres Mossfiel Medical Centre, Point Cook Medical Centre, Princes Highway Medical Centre, Iramoo Medical Centre, Cairnlea Superclinic, Isis Primary Care, Civic Parade Medical Centre, Thomastown Superclinic, Westgate Health Co-operative, Hoppers Crossing Medical Centre, Fawkner Family Medical Centre, Wingrove Medical Centre, Laurimar Medical Centre, Thomas Street Family Medical Centre, Circle Surgery, Laverton Medical Centre, The Clinic Werribee, Hampstead Drive Medical Centre, Westgate Medical Centre, Wyndhamvale Health Care, Murchison Medical Centre, Altona Superclinic, and assistance from Hanan Derraz CDE-RN, Dr Bala Krishnamurthy, Dr Kylie Maclachlan, Dr Jason Galanos, Ms Brenda Cayzer, Ms Fiona Weedon and Dr Ken Sikaris from Melbourne Pathology. We thank participating patients for their support.