Genome-wide association study identifies multiple susceptibility loci for diffuse large B cell lymphoma

JR Cerhan; SI Berndt; J Vijai; H Ghesquières; J McKay; SS Wang; Z Wang; M Yeager; L Conde; PIW De Bakker; A Nieters; D Cox; L Burdett; A Monnereau; CR Flowers; AJ De Roos; AR Brooks-Wilson; Q Lan; G Severi; M Melbye; J Gu; RD Jackson; E Kane; LR Teras; MP Purdue; CM Vajdic; JJ Spinelli; GG Giles; D Albanes; RS Kelly; M Zucca; KA Bertrand; A Zeleniuch-Jacquotte; C Lawrence; A Hutchinson; D Zhi; TM Habermann; BK Link; AJ Novak; A Dogan; YW Asmann; M Liebow; CA Thompson; SM Ansell; TE Witzig; GJ Weiner; AS Veron; D Zelenika; H Tilly; C Haioun; TJ Molina; H Hjalgrim; B Glimelius; HO Adami; PM Bracci; J Riby; MT Smith; EA Holly; W Cozen; P Hartge; LM Morton; RK Severson; LF Tinker; KE North; N Becker; Y Benavente; P Boffetta; P Brennan; L Foretova; M Maynadie; A Staines; T Lightfoot; S Crouch; A Smith; E Roman; WR Diver; K Offit; A Zelenetz; RJ Klein; DJ Villano; T Zheng; Y Zhang; TR Holford; A Kricker; J Turner; MC Southey; J Clavel; J Virtamo; S Weinstein; E Riboli; P Vineis; R Kaaks; D Trichopoulos; RCH Vermeulen; H Boeing; A Tjonneland; E Angelucci; S Di Lollo; M Rais; BM Birmann

Journal article

Genome-wide association study identifies multiple susceptibility loci for diffuse large B cell lymphoma

JR Cerhan, SI Berndt, J Vijai, H Ghesquières, J McKay, SS Wang, Z Wang, M Yeager, L Conde, PIW De Bakker, A Nieters, D Cox, L Burdett, A Monnereau, CR Flowers, AJ De Roos, AR Brooks-Wilson, Q Lan, G Severi, M Melbye Show all

Nature Genetics | Published : 2014

DOI: 10.1038/ng.3105

Abstract

Diffuse large B cell lymphoma (DLBCL) is the most common lymphoma subtype and is clinically aggressive. To identify genetic susceptibility loci for DLBCL, we conducted a meta-analysis of 3 new genome-wide association studies (GWAS) and 1 previous scan, totaling 3,857 cases and 7,666 controls of European ancestry, with additional genotyping of 9 promising SNPs in 1,359 cases and 4,557 controls. In our multi-stage analysis, five independent SNPs in four loci achieved genome-wide significance marked by rs116446171 at 6p25.3 (EXOC2; P = 2.33 × 10 '21), rs2523607 at 6p21.33 (HLA-B; P = 2.40 × 10 '10), rs79480871 at 2p23.3 (NCOA1; P = 4.23 × 10 '8) and two independent SNPs, rs13255292 and rs473360..

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University of Melbourne Researchers

Graham Giles Author

Melissa Southey Author

Grants

Awarded by National Cancer Institute

Funding Acknowledgements

We thank C. Allmer, E. Angelucci, A. Bigelow, S. Buehler, K. Butterbach, A. Chabrier, J.M. Conners, M. Corines, M. Cornelis, K. Corsano, H. Dykes, L. Ershler, A. Gabbas, R.P. Gallagher, R.D. Gascoyne, P. Hui, L. Irish, L. Jacobus, L. Klareskog, A.S. Lai, J. Lunde, M. McAdams, R. Montalvan, L. Padyukov, M. Rais, T. Rattle, L. Rigacci, K. Snyder, G. Specchia, M. Stagner, G. Thomas, C. Tornow, G. Wood and M. Yang. The overall GWAS project was supported by the Intramural Program of the US National Institutes of Health/National Cancer Institute. A list of support provided to individual studies appears in the Supplementary Note.