An adverse lipid profile is associated with disability and progression in disability, in people with MS
Prudence Tettey, Steve Simpson, Bruce Taylor, Leigh Blizzard, Anne-Louise Ponsonby, Terence Dwyer, Karam Kostner, Ingrid van der Mei
Multiple Sclerosis Journal | SAGE PUBLICATIONS LTD | Published : 2014
BACKGROUND: There is accumulating data suggesting an association between serum lipids, apolipoproteins and disability in multiple sclerosis (MS). OBJECTIVES: To investigate the associations between serum lipids, apolipoproteins and disability in MS. METHODS: A cohort of 178 participants with clinically-definite MS in southern Tasmania, Australia were prospectively followed from 2002 - 2005, and serum samples were obtained at study entry and at each biannual review, to measure lipid profile and apolipoprotein levels. Associations with disability and annual change in disability were evaluated using linear regression and multilevel mixed-effects linear regression. RESULTS: In the unadjusted ana..View full abstract
Awarded by Australian National Health & Medical Research Council
The MS Longitudinal Study was funded by a grant from the Australian National Health & Medical Research Council (Project 211308). The Trish Foundation provided funding for the 25(OH)D measures. MS Research Australia provided funding for the serum lipid measures. IvdM is funded by an Australian Research Council Future Fellowship, and SSJr by an MS Research Australia Fellowship.