An adverse lipid profile is associated with disability and progression in disability, in people with MS

Abstract

Background: There is accumulating data suggesting an association between serum lipids, apolipoproteins and disability in multiple sclerosis (MS).Objectives: To investigate the associations between serum lipids, apolipoproteins and disability in MS.Methods: A cohort of 178 participants with clinically-definite MS in southern Tasmania, Australia were prospectively followed from 2002-2005, and serum samples were obtained at study entry and at each biannual review, to measure lipid profile and apolipoprotein levels. Associations with disability and annual change in disability were evaluated using linear regression and multilevel mixed-effects linear regression.Results: In the unadjusted analyses..