Journal article
Seizure expression, behavior, and brain morphology differences in colonies of Genetic Absence Epilepsy Rats from Strasbourg
KL Powell, H Tang, C Ng, I Guillemain, G Dieuset, G Dezsi, N Çarçak, F Onat, B Martin, TJ O'Brien, A Depaulis, NC Jones
Epilepsia | WILEY | Published : 2014
DOI: 10.1111/epi.12840
Abstract
Objective Originally derived from a Wistar rat strain, a proportion of which displayed spontaneous absence-type seizures, Genetic Absence Epilepsy Rats from Strasbourg (GAERS) represent the most widely utilized animal model of genetic generalized epilepsy. Here we compare the seizure, behavioral, and brain morphometric characteristics of four main GAERS colonies that are being actively studied internationally: two from Melbourne (MELB and STRAS-MELB), one from Grenoble (GREN), and one from Istanbul (ISTAN). Methods Electroencephalography (EEG) recordings, behavioral examinations, and structural magnetic resonance imaging (MRI) studies were conducted on GAERS and Non-Epileptic Control (NEC) r..
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Awarded by Marmara University Research Council (BAPKO)
Funding Acknowledgements
We thank Olivier David for providing MRI images of GREN colonies and his very useful help in data analysis. This study was supported by Marmara University Research Council (BAPKO, SAG-D-060510-127) to FO and NC, by a fellowship grant from UCB Pharma (France) to GD, and by Inserm and the University Joseph Fourier to AD and IG.