Journal article
Signatures of tumour immunity distinguish Asian and non-Asian gastric adenocarcinomas
SJ Lin, JA Gagnon-Bartsch, IB Tan, S Earle, L Ruff, K Pettinger, B Ylstra, N Van Grieken, SY Rha, HC Chung, JS Lee, JH Cheong, SH Noh, T Aoyama, Y Miyagi, A Tsuburaya, T Yoshikawa, JA Ajani, A Boussioutas, KG Yeoh Show all
Gut | BMJ PUBLISHING GROUP | Published : 2015
Open access
Abstract
Objective: Differences in gastric cancer (GC) clinical outcomes between patients in Asian and non-Asian countries has been historically attributed to variability in clinical management. However, recent international Phase III trials suggest that even with standardised treatments, GC outcomes differ by geography. Here, we investigated gene expression differences between Asian and non-Asian GCs, and if these molecular differences might influence clinical outcome. Design: We compared gene expression profiles of 1016 GCs from six Asian and three non-Asian GC cohorts, using a two-stage meta-analysis design and a novel biostatistical method (RUV-4) to adjust for technical variation between cohorts..
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Awarded by National Cancer Institute
Funding Acknowledgements
We acknowledge the technical assistance by Alex Wright (Leeds) for the automated image analysis. PT and HG contributed equally to this study. This work was supported by NMRC Singapore grants TCR/009-NUHS/2013 (PT), core grant support from Genome Institute of Singapore (PT); Association of Clinical Pathologists (SE); Pathological Society of Great Britain and Ireland (HG, TA); The Great Britain Sasakawa Foundation (HG, TY); Non-Profit Organisation Kanagawa Standard Anti-cancer Therapy Support System (AT, TY); NIH USA (R01CA150229) grant support to JL; and an NHMRC Australia Fellowship to TS.