Journal article
Variation at HLA-DRB1 is associated with resistance to enteric fever
SJ Dunstan, NT Hue, B Han, Z Li, TTB Tram, KS Sim, CM Parry, NT Chinh, H Vinh, NPH Lan, NTV Thieu, PV Vinh, S Koirala, S Dongol, A Arjyal, A Karkey, O Shilpakar, C Dolecek, JN Foo, LT Phuong Show all
Nature Genetics | Published : 2014
DOI: 10.1038/ng.3143
Abstract
Enteric fever affects more than 25 million people annually and results from systemic infection with Salmonella enterica serovar Typhi or Paratyphi pathovars A, B or C 1. We conducted a genome-wide association study of 432 individuals with blood culture-confirmed enteric fever and 2,011 controls from Vietnam. We observed strong association at rs7765379 (odds ratio (OR) for the minor allele = 0.18, P = 4.5 × 10 â '10), a marker mapping to the HLA class II region, in proximity to HLA-DQB1 and HLA-DRB1. We replicated this association in 595 enteric fever cases and 386 controls from Nepal and also in a second independent collection of 151 cases and 668 controls from Vietnam. Imputation-based fine..
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Awarded by National Institutes of Health
Funding Acknowledgements
This work was supported by the Wellcome Trust, UK as part of their Major Overseas Program in Viet Nam (089276/Z/09/Z) and by the Biomedical Research Council, Agency for Science, Technology and Research, Singapore. S.B. is a Sir Henry Dale Fellow, jointly funded by the Wellcome Trust and the Royal Society (100087/Z/12/Z). P.I.W.d.B. acknowledges support from the Netherlands Organization for Scientific Research (Vernieuwingsimpuls VIDI Award NWO project number 016.126.354).