Journal article
Platelets from children are hyper-responsive to activation by thrombin receptor activator peptide and adenosine diphosphate compared to platelets from adults
C Yip, MD Linden, C Attard, P Monagle, V Ignjatovic
British Journal of Haematology | Published : 2015
DOI: 10.1111/bjh.13153
Abstract
Summary: Platelets are crucial subcellular elements of haemostasis at sites of vascular injury and are also known to be immune mediators in pathological thrombosis. Despite the integral role of platelets in many disease processes, there is very little information available on platelet function and response to agonists in healthy children. We recently reported important differences in the interaction of platelets with monocytes in the circulation, including increased formation of monocyte-platelet aggregates (MPAs) without concomitant increase in P-selectin expression. Our current study investigates parameters of platelet activation (PAC-1 binding and P-selectin expression) and MPA formation ..
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Funding Acknowledgements
We would like to thank Ms. Sophie Jones and Dr. David Hughes for the recruitment of adult donors and sample collection; Dr. Matthew Burton for advice on flow cytometry; Professor Susan Donath from the Clinical Epidemiology and Biostatistics Unit for advice on statistical analysis and members of the anaesthetic and surgical departments of the Royal Children's Hospital, Melbourne, for facilitating collection of paediatric samples. C. Yip acknowledges support from Singapore National University Hospital (Talent Development Award program). This study was supported by the Victorian Government's Operational Infrastructure Support Program.