An In Silico Agent-Based Model Demonstrates Reelin Function in Directing Lamination of Neurons during Cortical Development
James R Caffrey, Barry D Hughes, Joanne M Britto, Kerry A Landman
PLOS ONE | PUBLIC LIBRARY SCIENCE | Published : 2014
The characteristic six-layered appearance of the neocortex arises from the correct positioning of pyramidal neurons during development and alterations in this process can cause intellectual disabilities and developmental delay. Malformations in cortical development arise when neurons either fail to migrate properly from the germinal zones or fail to cease migration in the correct laminar position within the cortical plate. The Reelin signalling pathway is vital for correct neuronal positioning as loss of Reelin leads to a partially inverted cortex. The precise biological function of Reelin remains controversial and debate surrounds its role as a chemoattractant or stop signal for migrating n..View full abstract
Related Projects (1)
Awarded by Australian Research Council
The work was supported by Australian Research Council, Discovery project DP140100339. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.