Arousal from Sleep Does Not Lead to Reduced Dilator Muscle Activity or Elevated Upper Airway Resistance on Return to Sleep in Healthy Individuals
Amy S Jordan, Jennifer M Cori, Andrew Dawson, Christian L Nicholas, Fergal J O'Donoghue, Peter G Catcheside, Danny J Eckert, R Doug McEvoy, John Trinder
Sleep | OXFORD UNIV PRESS INC | Published : 2015
STUDY OBJECTIVES: To compare changes in end-tidal CO2, genioglossus muscle activity and upper airway resistance following tone-induced arousal and the return to sleep in healthy individuals with small and large ventilatory responses to arousal. DESIGN: Observational study. SETTING: Two sleep physiology laboratories. PATIENTS OR PARTICIPANTS: 35 men and 25 women with no medical or sleep disorders. INTERVENTIONS: Auditory tones to induce 3-s to 15-s cortical arousals from sleep. MEASUREMENTS AND RESULTS: During arousal from sleep, subjects with large ventilatory responses to arousal had higher ventilation (by analytical design) and tidal volume, and more marked reductions in the partial pressu..View full abstract
Awarded by Australian Research Council
Awarded by National Health and Medical Research Council of Australia
This was not an industry supported study. This work was supported by grants from the Australian Research Council (FT100100203), National Health and Medical Research Council of Australia (138403 and 430300) and the University of Melbourne Faculty Research Grant Support Scheme. The data was collected at both the Adelaide Institute for Sleep Health, Daw Park, SA, Australia and University of Melbourne, Parkville VIC, Australia. The authors have indicated no financial conflicts of interest.