Arousal from Sleep Does Not Lead to Reduced Dilator Muscle Activity or Elevated Upper Airway Resistance on Return to Sleep in Healthy Individuals

Amy S Jordan; Jennifer M Cori; Andrew Dawson; Christian L Nicholas; Fergal J O'Donoghue; Peter G Catcheside; Danny J Eckert; R Doug McEvoy; John Trinder

Journal article

Arousal from Sleep Does Not Lead to Reduced Dilator Muscle Activity or Elevated Upper Airway Resistance on Return to Sleep in Healthy Individuals

Amy S Jordan, Jennifer M Cori, Andrew Dawson, Christian L Nicholas, Fergal J O'Donoghue, Peter G Catcheside, Danny J Eckert, R Doug McEvoy, John Trinder

SLEEP | OXFORD UNIV PRESS INC | Published : 2015

DOI: 10.5665/sleep.4324

Abstract

STUDY OBJECTIVES: To compare changes in end-tidal CO2, genioglossus muscle activity and upper airway resistance following tone-induced arousal and the return to sleep in healthy individuals with small and large ventilatory responses to arousal. DESIGN: Observational study. SETTING: Two sleep physiology laboratories. PATIENTS OR PARTICIPANTS: 35 men and 25 women with no medical or sleep disorders. INTERVENTIONS: Auditory tones to induce 3-s to 15-s cortical arousals from sleep. MEASUREMENTS AND RESULTS: During arousal from sleep, subjects with large ventilatory responses to arousal had higher ventilation (by analytical design) and tidal volume, and more marked reductions in the partial pressu..

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University of Melbourne Researchers

Fergal O'Donoghue Author Medical Education

Amy Jordan Author Melbourne School of Psychological Sciences

Christian Nicholas Author Melbourne School of Psychological Sciences

Related Projects (1)

Assessing a model of the physiological changes at arousal from sleep.

Arousals from sleep are common in the elderly and have adverse consequences. This project will investigate a model of the changes in bodily ..

Grants

Awarded by Australian Research Council

Awarded by National Health and Medical Research Council of Australia

Funding Acknowledgements

This was not an industry supported study. This work was supported by grants from the Australian Research Council (FT100100203), National Health and Medical Research Council of Australia (138403 and 430300) and the University of Melbourne Faculty Research Grant Support Scheme. The data was collected at both the Adelaide Institute for Sleep Health, Daw Park, SA, Australia and University of Melbourne, Parkville VIC, Australia. The authors have indicated no financial conflicts of interest.