Bindarit, an Inhibitor of Monocyte Chemotactic Protein Synthesis, Protects against Bone Loss Induced by Chikungunya Virus Infection
Weiqiang Chen, Suan-Sin Foo, Adam Taylor, Aleksei Lulla, Andres Merits, Linda Hueston, Mark R Forwood, Nicole C Walsh, Natalie A Sims, Lara J Herrero, Suresh Mahalingam
Journal of Virology | AMER SOC MICROBIOLOGY | Published : 2015
UNLABELLED: The recent global resurgence of arthritogenic alphaviruses, in particular chikungunya virus (CHIKV), highlights an urgent need for the development of therapeutic intervention strategies. While there has been significant progress in defining the pathophysiology of alphaviral disease, relatively little is known about the mechanisms involved in CHIKV-induced arthritis or potential therapeutic options to treat the severe arthritic symptoms associated with infection. Here, we used microcomputed tomographic (μCT) and histomorphometric analyses to provide previously undescribed evidence of reduced bone volume in the proximal tibial epiphysis of CHIKV-infected mice compared to the result..View full abstract
Awarded by Australian National Health and Medical Research Council (NHMRC)
This work was supported by Australian National Health and Medical Research Council (NHMRC) grants (628011 and 1033068) to S.M. A.T. is the recipient of a NHMRC Peter Doherty Early Career Fellowship, L.J. is the recipient of an Australian Research Council Discovery Early Career Researcher Award, and S.M. is the recipient of an NHMRC Senior Research Fellowship.