Alpha-synuclein oligomers and fibrils originate in two distinct conformer pools: a small angle X-ray scattering and ensemble optimisation modelling study

Cyril C Curtain; Nigel M Kirby; Haydyn DT Mertens; Kevin J Barnham; Robert B Knott; Colin L Masters; Roberto Cappai; Agata Rekas; Vijaya B Kenche; Timothy Ryan

Journal article

Alpha-synuclein oligomers and fibrils originate in two distinct conformer pools: a small angle X-ray scattering and ensemble optimisation modelling study

Cyril C Curtain, Nigel M Kirby, Haydyn DT Mertens, Kevin J Barnham, Robert B Knott, Colin L Masters, Roberto Cappai, Agata Rekas, Vijaya B Kenche, Timothy Ryan

MOLECULAR BIOSYSTEMS | ROYAL SOC CHEMISTRY | Published : 2015

DOI: 10.1039/c4mb00356j

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University of Melbourne Researchers

Kevin Barnham Author Florey Department of Neuroscience and Mental Health

Colin Masters Author Florey Department of Neuroscience and Mental Health

Roberto Cappai Author Pharmacology and Therapeutics

Vijaya Kenche Author Clinical Pathology

Cyril Curtain Author Clinical Pathology

Grants

Funding Acknowledgements

The authors wish to acknowledge the support of the Australian Synchrotron and the Victorian Government Operational Infrastructure Support Program. TMR is supported by the Australian Alzheimer's disease foundation. CLM and KJB are consultants for Prana Biotechnology Pty Ltd. CLM, KJB and RC are the principal investigators on an Australian National Health and Medical Research Council program grant.