Amino-terminal-pro-B-type natriuretic peptide levels and low diastolic blood pressure: potential relevance to the diastolic J-curve
Duncan J Campbell, Michele McGrady, David L Prior, Jennifer M Coller, Umberto Boffa, Louise Shiel, Danny Liew, Rory Wolfe, Simon Stewart, Christopher M Reid, Henry Krum
JOURNAL OF HYPERTENSION | LIPPINCOTT WILLIAMS & WILKINS | Published : 2014
BACKGROUND: There is debate whether the J-curve relationship between cardiac event risk and DBP is because of inherent cardiac risk or is a consequence of blood pressure (BP) lowering therapy. METHODS: We examined the association between the cardiovascular risk marker amino-terminal-pro-B-type natriuretic peptide (NT-proBNP) and DBP in 1781 women and 2211 men aged at least 60 years with one or more cardiovascular risk factors; exclusion criteria were known heart failure or cardiac abnormality on a cardiac imaging study. RESULTS: The lowest median serum NT-proBNP levels were for DBP 85-89 mmHg for both women and men. DBP less than 70 mmHg in women and less than 80 mmHg in men was associated w..View full abstract
Funding: The SCREEN-HF study was initially funded by Bupa Australia, with subsequent support from the National Health and Medical Research Council (NHMRC) of Australia and the National Heart Foundation of Australia. D.C., C.M.R. and S.S. received senior research fellowships from the NHMRC, and M.M. and J.C. received scholarship support from the NHMRC. St Vincent's Institute of Medical Research is supported in part by the Victorian Government's Operational Infrastructure Support Program.