Journal article
CD14 polymorphisms, microbial exposure and allergic diseases: A systematic review of gene-environment interactions
MYZ Lau, SC Dharmage, JA Burgess, AJ Lowe, CJ Lodge, B Campbell, MC Matheson
Allergy European Journal of Allergy and Clinical Immunology | Published : 2014
DOI: 10.1111/all.12454
Abstract
Asthma and allergy may develop as a result of interactions between environmental factors and the genetic characteristics of an individual. This review aims to summarize the available evidence for, and potential effects of, an interaction between polymorphisms of the CD14 gene and exposure to microbes on the risk of asthma and allergic diseases. We searched PubMed, MEDLINE and Global Health databases, finding 12 articles which met inclusion criteria. Most studies reported a significant interaction between CD14 polymorphisms and microbial exposure. When stratified by age at microbial exposure (early life vs adult life), there was evidence of a protective effect of gene-environment interaction ..
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Funding Acknowledgements
ML is supported by Marjory Edwards OAM PhD Scholarship from the Asthma Australia. SD, MM, JB, AL and CL are all supported by the National Health and Medical Research Council of Australia (NHMRC).