A systematic and functional classification of Streptococcus pyogenes that serves as a new tool for molecular typing and vaccine development

M Sanderson-Smith; DMP De Oliveira; J Guglielmini; DJ McMillan; T Vu; JK Holien; A Henningham; AC Steer; DE Bessen; JB Dale; N Curtis; BW Beall; MJ Walker; MW Parker; JR Carapetis; L Van Melderen; KS Sriprakash; PR Smeesters; M Batzloff; R Towers; H Goossens; S Malhotra-Kumar; L Guilherme; R Torres; D Low; A McGeer; P Krizova; S El Tayeb; J Kado; M Van Der Linden; G Erdem; A Moses; R Nir-Paz; T Ikebe; H Watanabe; S Sow; B Tamboura; B Kittang; J Melo-Cristino; M Ramirez; M Straut; A Suvorov; A Totolian; M Engel; B Mayosi; A Whitelaw; J Darenberg; BH Normark; CC Ni; JJ Wu; A De Zoysa; A Efstratiou; S Shulman; R Tanz

Journal article

A systematic and functional classification of Streptococcus pyogenes that serves as a new tool for molecular typing and vaccine development

M Sanderson-Smith, DMP De Oliveira, J Guglielmini, DJ McMillan, T Vu, JK Holien, A Henningham, AC Steer, DE Bessen, JB Dale, N Curtis, BW Beall, MJ Walker, MW Parker, JR Carapetis, L Van Melderen, KS Sriprakash, PR Smeesters, M Batzloff, R Towers Show all

Journal of Infectious Diseases | Published : 2014

DOI: 10.1093/infdis/jiu260

Abstract

Streptococcus pyogenes ranks among the main causes of mortality from bacterial infections worldwide. Currently there is no vaccine to prevent diseases such as rheumatic heart disease and invasive streptococcal infection. The streptococcal M protein that is used as the substrate for epidemiological typing is both a virulence factor and a vaccine antigen. Over 220 variants of this protein have been described, making comparisons between proteins difficult, and hindering M protein-based vaccine development. A functional classification based on 48 emm-clusters containing closely related M proteins that share binding and structural properties is proposed. The need for a paradigm shift from type-sp..

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University of Melbourne Researchers

Andrew Steer Author

Nigel Curtis Author

Michael Parker Author

Grants

Awarded by National Institute of Allergy and Infectious Diseases

Funding Acknowledgements

This project has been funded by the European Society for Clinical Microbiology and Infectious Diseases, European Society for Paediatric Infectious Diseases, Fonds National de la Recherche Scientifique (Belgium), Fonds Brachet and Fondation Van Buuren (Belgium), Australian National Health and Medical Research Council (Australia) and the National Institutes of Health (USA). Funding was also obtained from the Victorian Government Operational Infrastructure Support Scheme to St Vincent's Institute and Murdoch Childrens Research Institute. M. S.-S. is an NHMRC Career Development Fellow. M. W. P. is an NHMRC Senior Principal Research Fellow. J. K. H. is a joint Cure Cancer/Leukaemia Foundation Postdoctoral Fellow. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.