Pristinamycin: Old drug, new tricks?

Abstract

Osteoarticular infections with Gram positive bacteria present an increasing challenge in an era of multidrugresistant organisms. Prolonged intravenous antibiotic treatment is often required, with associated risks, costs and difficulties with administration; a safe, effective oral option would be ideal for this indication. Pristinamycin, an oral streptogramin antibiotic with bactericidal activity against Gram positive organisms including methicillin-resistant Staphylococcus aureus, has been used for over 50 years in Europe for the treatment of osteoarticular infections. We review the published evidence for the treatment of native bone and prosthesisrelated osteoarticular infections with prist..