Exhaled Breath Condensate Pepsin: Potential Noninvasive Test for Gastroesophageal Reflux in COPD and Bronchiectasis
Annemarie L Lee, Brenda M Button, Linda Denehy, Stuart Roberts, Tiffany Bamford, Fi-Tjen Mu, Nicole Mifsud, Robert Stirling, John W Wilson
RESPIRATORY CARE | DAEDALUS ENTERPRISES INC | Published : 2015
BACKGROUND: Acid gastroesophageal reflux is a common problem in non-cystic fibrosis bronchiectasis and COPD. Invasive methods are used to diagnose gastroesophageal reflux, but the ability to detect pulmonary microaspiration of gastric contents using this method is unclear. A noninvasive option to detect pulmonary microaspiration is to measure pepsin in exhaled breath condensate (EBC), but this has not been related to esophageal pH monitoring in these lung conditions. This study aimed to measure pepsin concentrations and pH in EBC and to determine the relationship to gastroesophageal reflux in bronchiectasis or COPD. METHODS: Subjects with bronchiectasis (n=10) or COPD (n=10) and control subj..View full abstract
This study was supported in part by the Physiotherapy Research Foundation of the Australian Physiotherapy Association and by the Australian National Health and Medical Research Council. The authors have disclosed no conflicts of interest.