The Contribution of Childhood Cardiorespiratory Fitness and Adiposity to Inflammation in Young Adults
Cong Sun, Costan G Magnussen, Anne-Louise Ponsonby, Michael D Schmidt, John B Carlin, Huynh Quan, Alison J Venn, Terence Dwyer
Obesity | WILEY | Published : 2014
OBJECTIVE: Cardiorespiratory fitness and adiposity may influence cardiovascular risk through their effects on inflammation. The long-term effects of these modifiable factors on adult inflammation remain uncertain. The associations of childhood and adulthood cardiorespiratory fitness and adiposity with adult inflammation [C-reactive protein (CRP), fibrinogen] were examined. METHODS: 1,976 children examined in 1985 and re-examined as young adults in 2004-2006 were included. Cardiorespiratory fitness and adiposity were assessed at both waves. CRP and fibrinogen were measured at follow-up. RESULTS: Higher childhood fitness was associated with lower adult inflammation in both sexes. After adjusti..View full abstract
Awarded by Australian National Health and Medical Research Council (NHMRC) Early Career Public Health Fellowships
Awarded by NHMRC
Funding agencies: C. S. and C. G. M were supported by the Australian National Health and Medical Research Council (NHMRC) Early Career Public Health Fellowships (grant 1013535 and 1037559). The Childhood Determinants of Adult Health Study was supported by the NHMRC project grant (211316), the Australian National Heart Foundation, the Tasmanian Community Fund, Veolia Environmental Services, the Sanitarium Health Food Company, ASICS Oceania, and Target Australia. No funding organization had any role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; or preparation of the manuscript.