Journal article

Prenatal Nicotine Exposure Selectively Affects Nicotinic Receptor Expression in Primary and Associative Visual Cortices of the Fetal Baboon

Jhodie R Duncan, Marianne Garland, Raymond I Stark, Michael M Myers, William P Fifer, David J Mokler, Hannah C Kinney

BRAIN PATHOLOGY | WILEY-BLACKWELL | Published : 2015

Abstract

Exposure to nicotine during pregnancy via maternal cigarette smoking is associated with visual deficits in children. This is possibly due to the activation of nicotinic acetylcholine receptors (nAChRs) in the occipital cortex, which are important in the development of visual mapping. Using a baboon model, we explored the effects of prenatal nicotine on parameters in the primary and associated visual cortices. Pregnant baboons were infused with nicotine (0.5 mg/h, intravenous) or saline from 86 days gestation. At 161 days gestation, fetal brains were collected (n = 5 per group) and the occipital lobe assessed for nAChRs and markers of the serotonergic and catecholaminergic systems using tissu..

View full abstract

University of Melbourne Researchers

Grants

Awarded by CJ Martin Fellowship (National Health and Medical Research Council)


Awarded by Australian Research Council


Awarded by National Institute of Child Health and Development


Awarded by EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH &HUMAN DEVELOPMENT


Funding Acknowledgements

The authors thank May Yang (MPH) for her assistance with the statistical analysis, and Richard A. Belliveau, Tung-wah Kiu, and Salha S. Daniel for assistance with experimental aspects of this work. Thus study was supported by the First Candle/SIDS Alliance, the CJ Martin Fellowship (National Health and Medical Research Council 359250), the Australian Research Council of which JRD is a Future Fellow (100100235), a grant from the National Institute of Child Health and Development (P01 HD13063, RIS) and the Victorian Government's Operational Infrastructure Support Scheme. There are no conflicts of interest.