Development and reliability of retinal arteriolar central light reflex quantification system: A new approach for severity grading

Abstract

Purpose: To describe the methodology and assess the reliability of novel computer-based semiautomated software that quantifies retinal arteriolar central light reflex (CR) from digital retinal photographs.Methods: A total of 150 optic disc–centered digital color retinal photographs were selected from a population-based cross-sectional study of persons aged 40 to 80 years (the Singapore Malay Eye Study [SiMES]). Computer-assisted software was developed to quantify retinal arteriolar CR by selecting vessel edge points semiautomatically. This software then automatically computes the CR, vessel diameter, and the CR-to-vessel diameter ratio (CRR). Reliability was assessed using the intraclass cor..