Journal article
Mechanisms of glucocorticoid action and insensitivity in airways disease
C Boardman, L Chachi, A Gavrila, CR Keenan, MM Perry, YC Xia, H Meurs, P Sharma
Pulmonary Pharmacology and Therapeutics | Published : 2014
Abstract
Glucocorticoids are the mainstay for the treatment of chronic inflammatory diseases including asthma and chronic obstructive pulmonary disease (COPD). However, it has been recognized that glucocorticoids do not work well in certain patient populations suggesting reduced sensitivity. The ultimate biologic responses to glucocorticoids are determined by not only the concentration of glucocorticoids but also the differences between individuals in glucocorticoid sensitivity, which is influenced by multiple factors. Studies are emerging to understand these mechanisms in detail, which would help in increasing glucocorticoid sensitivity in patients with chronic airways disease. This review aims to h..
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Funding Acknowledgements
All authors declare no conflicts of interest. CB and MMP are supported by Imperial College, UK. AG is supported by studentship from College of Medicine, Biological Sciences and Psychology, University of Leicester, UK. YCX is supported by National Health and Medical Research Council, Australia. PS is supported by career development award from Alberta Innovates Health Solutions and Canadian Institute of Health Research/Canadian Lung Association/GlaxoSmithKline Rx&D Fellowship, Canada.