Journal article

Effect of Testosterone Treatment on Constitutional and Sexual Symptoms in Men With Type 2 Diabetes in a Randomized, Placebo-Controlled Clinical Trial

Emily J Gianatti, Philippe Dupuis, Rudolf Hoermann, Jeffrey D Zajac, Mathis Grossmann

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM | ENDOCRINE SOC | Published : 2014

Abstract

OBJECTIVE: The objective of the study was to assess the effect of T treatment on constitutional and sexual symptoms in men with type 2 diabetes (T2D). DESIGN: This was a randomized double-blind, parallel, placebo-controlled trial. SETTING: The study was conducted at a tertiary referral center. PATIENTS: Men aged 35-70 years with T2D, a hemoglobin A1c less than 8.5%, and a total T level less than 12.0 nmol/L (346 ng/dL) with mild to moderate aging male symptoms and erectile dysfunction. INTERVENTION: Eighty-eight participants were randomly assigned to 40 weeks of im T undecanoate (n = 45) or matching placebo (n = 43). MAIN OUTCOME MEASURES: Constitutional symptoms using the aging male symptom..

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Grants

Awarded by National Health and Medical Research Council of Australia Career Development Fellowship


Awarded by National Health and Medical Research Council Postgraduate Fellowship


Awarded by Cardiovascular-Lipid Research Grant Pfizer Australia


Funding Acknowledgements

M.G. was supported by a National Health and Medical Research Council of Australia Career Development Fellowship (Grant 1024139); and E.G. was supported by a National Health and Medical Research Council Postgraduate Fellowship (Grant 1018196), a Cardiovascular-Lipid Research Grant Pfizer Australia (Grant CR05.09), a Royal Australasian College of Physicians/Osteoporosis Australia Research Entry Grant, and a University of Melbourne Postgraduate Scholarship.The manuscript publication fees have been paid by the Department of Medicine, University of Melbourne, Austin Hospital. Bayer Pharma AG provided T undecanoate, placebo, and financial support to conduct the investifations but had no role in the trial design, data analyses, manuscript preparation, or the decision to submit the manuscript for publication.