Journal article

Chronic Hypertension Increases Susceptibility to Acute IOP Challenge in Rats

Zheng He, Algis J Vingrys, James A Armitage, Christine T Nguyen, Bang V Bui

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE | ASSOC RESEARCH VISION OPHTHALMOLOGY INC | Published : 2014

Abstract

PURPOSE: To consider the effect of chronic arterial hypertension on the susceptibility of the retina to acute IOP challenge. METHODS: Anesthetized adult Long-Evans rats with normal (n = 5, receiving saline subcutaneously), chronic high blood pressure (BP) for 4 weeks (n = 15, Angiotensin II subcutaneously), and acute high BP for 1 hour (n = 10, Angiotensin II intravenously) underwent IOP elevation (10-120 mm Hg, 5 mm Hg steps each 3 minutes). During IOP elevation, retinal function and ocular blood flow were monitored with electroretinogram (ERG) and laser-Doppler flowmetry (LDF), respectively. Blood pressure was monitored via a femoral artery cannula. Electroretinogram and LDF responses are ..

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