Journal article
Chronic Hypertension Increases Susceptibility to Acute IOP Challenge in Rats
Zheng He, Algis J Vingrys, James A Armitage, Christine T Nguyen, Bang V Bui
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE | ASSOC RESEARCH VISION OPHTHALMOLOGY INC | Published : 2014
Abstract
PURPOSE: To consider the effect of chronic arterial hypertension on the susceptibility of the retina to acute IOP challenge. METHODS: Anesthetized adult Long-Evans rats with normal (n = 5, receiving saline subcutaneously), chronic high blood pressure (BP) for 4 weeks (n = 15, Angiotensin II subcutaneously), and acute high BP for 1 hour (n = 10, Angiotensin II intravenously) underwent IOP elevation (10-120 mm Hg, 5 mm Hg steps each 3 minutes). During IOP elevation, retinal function and ocular blood flow were monitored with electroretinogram (ERG) and laser-Doppler flowmetry (LDF), respectively. Blood pressure was monitored via a femoral artery cannula. Electroretinogram and LDF responses are ..
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Grants
Awarded by NHMRC Project (Melbourne, Victoria, Australia)
Funding Acknowledgements
The authors thank Jonathan Bensley and Debbie Arena from the Department of Anatomy and Developmental Biology, Monash University, who assisted in the histology assay and analysis. Supported by the NHMRC Project Grant (566570, 1046203; Melbourne, Victoria, Australia).