Journal article

Perinatal testosterone exposure and cerebral lateralisation in adult males: Evidence for the callosal hypothesis

Lauren P Hollier, Murray T Maybery, Jeffrey A Keelan, Martha Hickey, Andrew JO Whitehouse

Biological Psychology | ELSEVIER SCIENCE BV | Published : 2014

Abstract

Two competing theories address the influence of foetal testosterone on cerebral laterality: one proposing exposure to high foetal testosterone concentrations is related to atypical lateralisation (Geschwind-Galaburda hypothesis), the other that high foetal testosterone concentrations exaggerate typical lateralisation (callosal hypothesis). The current study examined the relationship between cord testosterone concentrations and cerebral laterality for language and spatial memory in adulthood. Male participants with high (>0.15nmol) and low (<0.10nmol) cord testosterone levels were invited to take part in the study (n=18 in each group). Cerebral laterality was measured using functional Transcr..

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Grants

Awarded by National Health and Medical Research Council (NHMRC)


Awarded by Practitioner Fellowship from the NHMRC


Funding Acknowledgements

The authors would like to acknowledge the National Health and Medical Research Council (NHMRC) and the Telethon Kids Institute for their long term contribution to funding the Raine study over the last 20 years. The androgen analysis was funded by Australian Rotary Health. Core Management of the Raine study has been funded by the University of Western Australia (UWA), Curtin University, the UWA Faculty of Medicine, Dentistry and Health Sciences, the Raine Medical Research Foundation, Telethon Kids Institute, and the Women's and Infants Research Foundation. AJOW is funded by a Career Development Fellowship (#1004065) from the National Health and Medical Research Council (NHMRC). MH is funded by a Practitioner Fellowship from the NHMRC (#1058935). JAK is funded by the Women and Infants' Research Foundation. The authors are extremely grateful to the study participants and their families, as well as the whole Raine Study Team which includes the Cohort Manager, Data Manager and data collection researchers.