Journal article
A clinicopathological and molecular analysis of 200 traditional serrated adenomas
ML Bettington, NI Walker, C Rosty, IS Brown, AD Clouston, DM McKeone, SA Pearson, K Klein, BA Leggett, VLJ Whitehall
Modern Pathology | Published : 2015
Abstract
The traditional serrated adenoma is the least common colorectal serrated polyp. The clinicopathological features and molecular drivers of these polyps require further investigation. We have prospectively collected a cohort of 200 ordinary and advanced traditional serrated adenomas and performed BRAF and KRAS mutational profiling, CpG island methylator phenotype analysis, and immunohistochemistry for a panel of 7 antibodies (MLH1, β-catenin, p53, p16, Ki67, CK7, and CK20) on all cases. The mean age of the patients was 64 years and 50% were female. Of the polyps, 71% were distal. Advanced histology (overt dysplasia or carcinoma) was present in 19% of cases. BRAF mutation was present in 67% and..
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Awarded by National Health and Medical Research Council
Funding Acknowledgements
We gratefully acknowledge NHMRC grant funding (ID: 1063105). Mark Bettington gratefully acknowledges PhD scholarship funding from Cancer Council Queensland. Thanks also to Madeleine Flynn (Graphics Support Unit, QIMR Berghofer Medical Research Institute) for assistance with image production.