Youth depression alleviation: the Fish Oil Youth Depression Study (YoDA-F): A randomized, double-blind, placebo-controlled treatment trial

SM Rice; IB Hickie; AR Yung; A Mackinnon; M Berk; C Davey; DF Hermens; SE Hetrick; AG Parker; MR Schäfer; PD McGorry; GP Amminger

Journal article

Youth depression alleviation: the Fish Oil Youth Depression Study (YoDA-F): A randomized, double-blind, placebo-controlled treatment trial

SM Rice, IB Hickie, AR Yung, A Mackinnon, M Berk, C Davey, DF Hermens, SE Hetrick, AG Parker, MR Schäfer, PD McGorry, GP Amminger

Early Intervention in Psychiatry | WILEY | Published : 2016

DOI: 10.1111/eip.12166

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Abstract

Aim: US authorities have recommended ‘black-box’ warnings for antidepressants because of the increased risk of suicidality for individuals up to age 25. There is thus a clinical and ethical imperative to provide effective treatment for youth depression with an acceptable risk–benefit balance. Long-chain omega-3 polyunsaturated fatty acids (PUFAs) play an important role in a range of physiological processes in living organisms. Supplementation with omega-3 PUFAs has been shown to have a range of beneficial effects on both physical and mental health, and results of previous trials suggest that omega-3 PUFAs may be a safe and effective treatment for depression. However, conclusions from these t..

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University of Melbourne Researchers

Simon Rice Author

Andrew MacKinnon Author

Michael Berk Author

Chris Davey Author

Related Projects (3)

THE FISH OIL YOUTH DEPRESSION STUDY

Long-chain omega-3 fatty acids (‘fish oil’) can reduce symptoms of depression. This, and the fact that they do not cause major side effects ..

MAPPING AND TREATING EARLY CLINICAL STAGES OF MENTAL DISORDERS DURING TRANSITION TO ADULTHOOD

The research proposed in this Fellowship is aimed at young people with emerging mental ill-health. The specific goals and targets are to for..

OPTIMISING EARLY INTERVENTIONS FOR YOUNG PEOPLE WITH EMERGING MOOD DISORDER

One of our greatest health challenges is to develop highly-personalised interventions for teenagers and young adults with emerging mood diso..

Grants

Awarded by beyondblue (National Priority Driven Research Program)

Awarded by National Health and Medical Research Council (NHMRC) Mental Health Targeted Call for Research

Awarded by NHMRC

Awarded by National Health and Medical Research Council of Australia

Funding Acknowledgements

The Fish Oil Youth Depression Study is funded by grants from beyondblue (2011 National Priority Driven Research Program; ID: 00096) and the National Health and Medical Research Council (NHMRC) 2012 Mental Health Targeted Call for Research (Application ID: 1042666). MB is supported by a NHMRC Senior Principal Research Fellowship 1059660. PM is supported by a NHMRC Senior Principal Research Fellowship 1060996. CD is supported by an NHMRC Career Development Fellowship 1061757. DFH is supported by a NHMRC Centre of Research Excellence 1061043.