Journal article

Nanosecond laser therapy reverses pathologic and molecular changes in age-related macular degeneration without retinal damage

AI Jobling, RH Guymer, KA Vessey, U Greferath, SA Mills, KH Brassington, CD Luu, KZ Aung, L Trogrlic, M Plunkett, EL Fletcher



Age-related macular degeneration (AMD) is a leading cause of vision loss, characterized by drusen deposits and thickened Bruch's membrane (BM). This study details the capacity of nanosecond laser treatment to reduce drusen and thin BM while maintaining retinal structure. Fifty patients with AMD had a single nanosecond laser treatment session and after 2 yr, change in drusen area was compared with an untreated cohort of patients. The retinal effect of the laser was determined in human and mouse eyes using immunohistochemistry and compared with untreated eyes. In a mouse with thickened BM (ApoEnull), the effect of laser treatment was quantified using electron microscopy and quantitative PCR. I..

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Awarded by National Health and Medical Research Council of Australia

Awarded by Centre for Clinical Research Excellence Award

Funding Acknowledgements

This work was supported by the National Health and Medical Research Council of Australia (#1038220 to E.L.F.and M.P.; #1061418 to E.L.F. and A.I.J.; #1061419 to E.L.F.and K.A.V.), practitioner fellowship (#529905 to R.H.G.) and the Victorian Science Agenda ( R.H.G., E.L.F., M.P.), Centre for Clinical Research Excellence Award (#529923 to R.H.G.). The Centre for Eye Research Australia receives Operational Infrastructure Support from the Victorian Government.At the time of this work, M.P. was employed by Ellex R&D Pty Ltd. All other authors declare no competing interests.