Journal article

Time Evolution of Deformation in a Human Cartilage Under Cyclic Loading

Lihai Zhang, Saeed Miramini, David W Smith, Bruce S Gardiner, Alan J Grodzinsky

Annals of Biomedical Engineering | SPRINGER | Published : 2015


Recent imaging has revealed that in vivo contact deformations of human knee cartilage under physiological loadings are surprisingly large-typically on the order of 10%, but up to 20 or 30% of tibiofemora cartilage thickness depending on loading conditions. In this paper we develop a biphasic, large deformation, non-linear poroelastic model of cartilage that can accurately represent the time dependence and magnitude of cyclic cartilage deformations in vivo. The model takes into account cartilage tension-compression nonlinearity and a new constitutive relation in which the compressive stiffness and hydraulic permeability of the cartilage adjusts in response to the strain-dependent aggrecan con..

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