Time Evolution of Deformation in a Human Cartilage Under Cyclic Loading
Lihai Zhang, Saeed Miramini, David W Smith, Bruce S Gardiner, Alan J Grodzinsky
Annals of Biomedical Engineering | SPRINGER | Published : 2015
Recent imaging has revealed that in vivo contact deformations of human knee cartilage under physiological loadings are surprisingly large-typically on the order of 10%, but up to 20 or 30% of tibiofemora cartilage thickness depending on loading conditions. In this paper we develop a biphasic, large deformation, non-linear poroelastic model of cartilage that can accurately represent the time dependence and magnitude of cyclic cartilage deformations in vivo. The model takes into account cartilage tension-compression nonlinearity and a new constitutive relation in which the compressive stiffness and hydraulic permeability of the cartilage adjusts in response to the strain-dependent aggrecan con..View full abstract
Awarded by Australian Government
Awarded by NIH
Awarded by NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES
The authors wish to thank the National Health and Medical Research Council, Australian Government (Grant Ref APP1051538) and NIH Grant AR060331 for support.