Drug targets in immunological diseases: Focus on rheumatoid arthritis.
Andrew D Cook, Kumar Visvanathan
Discov Med | Published : 2004
Extract: There are a large number of diseases involving inappropriate activation of the immune system. These are often classified as immune-mediated diseases and include autoimmune diseases such as rheumatoid arthritis (RA), multiple sclerosis, and type I diabetes mellitus, allergic diseases such as asthma, and immune-mediated graft/organ rejection. RA is a chronic systemic inflammatory disease involving the destruction of articular cartilage and bone in joints. Despite the advances in our understanding of RA, the cause remains elusive. It is now recognized that there are two arms to the disease, namely an inflammatory arm and a destructive arm. The inflammation causes many of the symptoms o..View full abstract