Journal article

Scrib:Rac1 interactions are required for the morphogenesis of the ventricular myocardium

Veronika Boczonadi, Rachel Gillespie, Iain Keenan, Simon A Ramsbottom, Charlotte Donald-Wilson, Mariana Al Nazer, Patrick Humbert, Robert J Schwarz, Bill Chaudhry, Deborah J Henderson

CARDIOVASCULAR RESEARCH | OXFORD UNIV PRESS | Published : 2014

Abstract

AIMS: The organization and maturation of ventricular cardiomyocytes from the embryonic to the adult form is crucial for normal cardiac function. We have shown that a polarity protein, Scrib, may be involved in regulating the early stages of this process. Our goal was to establish whether Scrib plays a cell autonomous role in the ventricular myocardium, and whether this involves well-known polarity pathways. METHODS AND RESULTS: Deletion of Scrib in cardiac precursors utilizing Scrib(flox) mice together with the Nkx2.5-Cre driver resulted in disruption of the cytoarchitecture of the forming trabeculae and ventricular septal defects. Although the majority of mice lacking Scrib in the myocardiu..

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