Scrib:Rac1 interactions are required for the morphogenesis of the ventricular myocardium
Veronika Boczonadi, Rachel Gillespie, Iain Keenan, Simon A Ramsbottom, Charlotte Donald-Wilson, Mariana Al Nazer, Patrick Humbert, Robert J Schwarz, Bill Chaudhry, Deborah J Henderson
CARDIOVASCULAR RESEARCH | OXFORD UNIV PRESS | Published : 2014
AIMS: The organization and maturation of ventricular cardiomyocytes from the embryonic to the adult form is crucial for normal cardiac function. We have shown that a polarity protein, Scrib, may be involved in regulating the early stages of this process. Our goal was to establish whether Scrib plays a cell autonomous role in the ventricular myocardium, and whether this involves well-known polarity pathways. METHODS AND RESULTS: Deletion of Scrib in cardiac precursors utilizing Scrib(flox) mice together with the Nkx2.5-Cre driver resulted in disruption of the cytoarchitecture of the forming trabeculae and ventricular septal defects. Although the majority of mice lacking Scrib in the myocardiu..View full abstract
Awarded by British Heart Foundation
This work was supported by the British Heart Foundation (PG/07/086 and PG/11/76/29108). Funding to pay the Open Access publication charges for this article was provided by the British Heart Foundation.