Journal article
Circulating fatty acids and prostate cancer risk: Individual participant meta-analysis of prospective studies
FL Crowe, PN Appleby, RC Travis, M Barnett, TM Brasky, HB Bueno-De-mesquita, V Chajes, JE Chavarro, MD Chirlaque, DR English, RA Gibson, GG Giles, GE Goodman, SM Henning, R Kaaks, IB King, LN Kolonel, AR Kristal, ML Neuhouser, SY Park Show all
Journal of the National Cancer Institute | Published : 2014
DOI: 10.1093/jnci/dju240
Abstract
Background: Individual studies have suggested that some circulating fatty acids are associated with prostate cancer risk, but have not been large enough to provide precise estimates of associations, particularly by stage and grade of disease.Methods: Principal investigators of prospective studies on circulating fatty acids and prostate cancer were invited to collaborate. Investigators provided individual participant data on circulating fatty acids (weight percent) and other characteristics of prostate cancer cases and controls. Prostate cancer risk by study-specific fifths of 14 fatty acids was estimated using multivariable-adjusted conditional logistic regression. All statistical tests were..
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Awarded by National Institutes of Health
Funding Acknowledgements
Centralized pooling, checking, and analysis of data were supported by Cancer Research UK (grant number C570/A11691). We thank the men who participated in the collaborating studies, the research staff, the collaborating laboratories, and the funding agencies in each of the studies. The Carotene and Retinol Efficacy Trial was supported by the National Cancer Institute at the National Institutes of Health (grants R01CA96789, U01CA63673, and N01PC35142). The Physicians' Health Study was supported by the US Department of Defence (grant W81XWH-11-1-0529) and the National Institutes of Health (grants CA42182, CA58684, CA90598, CA141298 CA97193, CA34944, CA40360, CA131945, P50CA90381, 1U54CA155626-01, P30DK046200, HL26490, and HL34595). SWOG's contribution of data from the Prostate Cancer Prevention Trial and the Selenium and Vitamin E Cancer Prevention Trial was supported by a NCI/DCP grant (CA37429).