Journal article

Trait positive affect is associated with hippocampal volume and change in caudate volume across adolescence

Meg Dennison, Sarah Whittle, Murat Yuecel, Michelle L Byrne, Orli Schwartz, Julian G Simmons, Nicholas B Allen



Trait positive affect (PA) in childhood confers both risk and resilience to psychological and behavioral difficulties in adolescence, although explanations for this association are lacking. Neurodevelopment in key areas associated with positive affect is ongoing throughout adolescence, and is likely to be related to the increased incidence of disorders of positive affect during this period of development. The aim of this study was to prospectively explore the relationship between trait indices of PA and brain development in subcortical reward regions during early to mid-adolescence in a community sample of adolescents. A total of 89 (46 male, 43 female) adolescents participated in magnetic r..

View full abstract


Awarded by National Health and Medical Research Council (NHMRC; Australia)

Awarded by Australian Research Council

Awarded by NHMRC

Funding Acknowledgements

This work was in part presented at the Society for Research in Adolescence (SRA) 13th Biennial Conference, Vancouver, Canada, March 8-10, 2012. No authors report competing interests. This research was supported by grants from the Colonial Foundation, the National Health and Medical Research Council (NHMRC; Australia; Program Grant No. 350241), and the Australian Research Council (Discovery Grant No. DP0878136). S.W. is supported by an NHMRC Career Development Fellowship (ID: 1007716). M.D. was supported by an Australian Postgraduate Award. M.Y. is supported by an NHMRC Fellowship (ID: 1021973). Our neuroimaging analysis was facilitated by the Neuropsychiatry Imaging Laboratory at the Melbourne Neuropsychiatry Centre. The authors thank the Brain Research Institute and Royal Children's Hospital for support in acquiring the neuroimaging data, as well as the families who participated in the study.