Journal article

Seasonal Variation of Relapse Rate in Multiple Sclerosis is Latitude Dependent

Tim Spelman, Orla Gray, Maria Trojano, Thor Petersen, Guillermo Izquierdo, Alessandra Lugaresi, Raymond Hupperts, Roberto Bergamaschi, Pierre Duquette, Pierre Grammond, Giorgio Giuliani, Cavit Boz, Freek Verheul, Celia Oreja-Guevara, Michael Barnett, Francois Grand'Maison, Maria Edite Rio, Jeannette Lechner-Scott, Vincent Van Pesch, Ricardo Fernandez Bolanos Show all

ANNALS OF NEUROLOGY | WILEY | Published : 2014

Abstract

OBJECTIVE: Previous studies assessing seasonal variation of relapse onset in multiple sclerosis have had conflicting results. Small relapse numbers, differing diagnostic criteria, and single region studies limit the generalizability of prior results. The aim of this study was to determine whether there is a temporal variation in onset of relapses in both hemispheres and to determine whether seasonal peak relapse probability varies with latitude. METHODS: The international MSBase Registry was utilized to analyze seasonal relapse onset distribution by hemisphere and latitudinal location. All analyses were weighted for the patient number contributed by each center. A sine regression model was u..

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Grants

Awarded by National Health and Medical Research Council (NHMRC)


Awarded by NHMRC


Awarded by NHMRC Center for Research Excellence grant


Funding Acknowledgements

This work was supported by the National Health and Medical Research Council (NHMRC) Career Development Award (Clinical) to H.B. (ID628856), an NHMRC project grant (1032484), an NHMRC Center for Research Excellence grant (1001216), and the MSBase Foundation.The MSBase Foundation is a not-for-profit organization that receives support from Merck Serono, Biogen Idec, Novartis Pharma, Bayer Schering, Sanofi-Aventis, and BioCSL.