Journal article
Environmental and genetic determinants of vitamin D insufficiency in 12-month-old infants
NHA Suaini, JJ Koplin, JA Ellis, RL Peters, AL Ponsonby, SC Dharmage, MC Matheson, M Wake, M Panjari, HTT Tan, PE Martin, A Pezic, AJ Lowe, D Martino, LC Gurrin, PJ Vuillermin, MLK Tang, KJ Allen
Journal of Steroid Biochemistry and Molecular Biology | Published : 2014
Abstract
We aimed to investigate the relationship between genetic and environmental exposure and vitamin D status at age one, stratified by ethnicity. This study included 563 12-month-old infants in the HealthNuts population-based study. DNA from participants' blood samples was genotyped using Sequenom MassARRAY MALDI-TOF system on 28 single nucleotide polymorphisms (SNPs) in six genes. Using logistic regression, we examined associations between environmental exposure and SNPs in vitamin D pathway and filaggrin genes and vitamin D insufficiency (VDI). VDI, defined as serum 25-hydroxyvitamin D3(25(OH)D3) level ≤50 nmol/L, was measured using liquid chromatography-tandem mass spectrometry (LC-MS/MS). In..
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Awarded by Sylvia and Charles Viertel Charitable Foundation
Funding Acknowledgements
This study was funded by the National Health & Medical Research Council (NHMRC) grant APP491233, Australia, the Ilhan Food Allergy Foundation, Anaphylaxi Stop, the Charles and Sylvia Viertel Medical Research Foundation and the Victorian Government's Operational Infrastructure Support Program. Skin prick test reagents were provided by ALK Abello, S.A. Madrid, Espana. Our study sponsors have had no involvement in: (1) the study design; (2) the collection, analysis, and interpretation of data; (3) the writing of the report; and (4) the decision to submit the paper for publication.