Journal article
Post-GWAS gene-environment interplay in breast cancer: Results from the Breast and Prostate Cancer Cohort Consortium and a meta-analysis on 79 000 women
M Barrdahl, F Canzian, AD Joshi, RC Travis, J Chang-Claude, PL Auer, SM Gapstur, M Gaudet, WR Diver, BE Henderson, CA Haiman, FR Schumacher, L Le Marchand, CD Berg, SJ Chanock, RN Hoover, A Rudolph, RG Ziegler, GG Giles, L Baglietto Show all
Human Molecular Genetics | Published : 2014
DOI: 10.1093/hmg/ddu223
Abstract
We studied the interplay between 39 breast cancer (BC) risk SNPs and established BC risk (body mass index, height, age at menarche, parity, age at menopause, smoking, alcohol and family history of BC) and prognostic factors (TNMstage, tumor grade, tumor size, age at diagnosis, estrogenreceptor statusandprogesterone receptor status) as joint determinants of BC risk. We used a nested case-control design within the National Cancer Institute's Breast and Prostate Cancer Cohort Consortium (BPC3), with 16 285 BC cases and 19 376 controls. We performed stratified analyses for both the risk and prognostic factors, testing for heterogeneity for the risk factors, and case-case comparisons for differen..
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Awarded by National Cancer Institute
Funding Acknowledgements
This work was supported by U.S. National Institutes of Health, National Cancer Institute (U19-CA148065, cooperative agreements U01-CA98233-07 to D. J.H., U01-CA98710-06 to M.J.T., U01-CA98216-06 to E.R. and R.K., and U01-CA98758-07 to B.E.H.) and Intramural Research Program of National Institutes of Health and National Cancer Institute, Division of Cancer Epidemiology and Genetics. The WHI program is funded by the National Heart, Lung, and Blood Institute, National Institutes of Health, U.S. Department of Health and Human Services through contracts HHSN268201100046C, HHSN268201100001C, HHS N268201100002C, HHSN268201100003C, HHSN2682011000 04C, and HHSN271201100004C. A full listing of WHI investigators can be found at: https://cleo.whi.org/researchers/Documents%20%20Write%20a%20Paper/WHI%20Investigator%20Short%20List.pdf. The Founding Sources had no role in the study design; in the collection, analysis and interpretation of data and in the decision to submit the paper for publication.