Journal article
Optical coherence tomography-defined changes preceding the development of drusen-associated atrophy in age-related macular degeneration
Z Wu, CD Luu, LN Ayton, JK Goh, LM Lucci, WC Hubbard, JL Hageman, GS Hageman, RH Guymer
Ophthalmology | Published : 2014
Abstract
Purpose: To characterize the pathological changes preceding the development of drusen-associated atrophy in eyes with age-related macular degeneration (AMD) using spectral-domain optical coherence tomography (SD-OCT). Design: Longitudinal and cross-sectional retrospective observational study. Participants: A total of 181 participants with intermediate AMD in at least 1 eye (141 unilateral, 40 bilateral) were assessed longitudinally. A total of 230 participants with bilateral intermediate AMD (40 longitudinal participants with an additional 190 participants) were analyzed cross-sectionally. Methods: Spectral-domain OCT, color fundus photography (CFP), near-infrared reflectance, and fundus aut..
View full abstractGrants
Awarded by National Institutes of Health
Funding Acknowledgements
Supported by the National Health and Medical Research Council (NHMRC) Project Grant (1027624), NHMRC practitioner fellowship (R. H. G., #529905), a Macular Degeneration Foundation Research Grant (G. S. H. and R. H. G.), National Institutes of Health Grant R24 EY017404 (G. S. H.), and an unrestricted grant to the University of Utah John A. Moran Eye Center and Department of Ophthalmology and Visual Sciences from Research to Prevent Blindness, Inc. Centre for Eye Research Australia receives Operational Infrastructure Support from the Victorian Government and is supported by an NHMRC Centre for Clinical Research Excellence Award (#529923).