Journal article

Arterial elasticity in obese adolescents with clinical features of insulin resistance

Mandy Ho, Paul Z Benitez-Aguirre, Kim C Donaghue, Paul Mitchell, Louise A Baur, Alicia J Jenkins, Maria E Craig, Chris T Cowell, Sarah P Garnett

DIABETES & VASCULAR DISEASE RESEARCH | SAGE PUBLICATIONS LTD | Published : 2015

Abstract

OBJECTIVE: To determine whether arterial elasticity differs between obese adolescents with clinical insulin resistance (IR), type 1 diabetes (T1D) and healthy non-obese controls. METHODS: This cross-sectional study evaluated 69 adolescents with clinical IR, 91 with T1D and 63 age-matched (10- to 18-year-old) controls. Arterial elasticity was measured using radial tonometry pulse-wave analysis. Stepwise multiple regression analyses were performed to assess the determinants of the small and large arterial elasticity indices (SAEI and LAEI). RESULTS: SAEI and LAEI raw values were higher in the IR group than the controls, and these did not differ between the T1D and control groups. Weight and di..

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Grants

Funding Acknowledgements

The RESIST study was funded by BUPA Foundation Australia Pty Limited (2008-2012), Diabetes Australia Research Trust (DART, 2008) and Heart Foundation, Australia (2009-2010). M.H. is supported by a National Health and Medical Research Council (NHMRC) Australian Dora Lush Postgraduate Research Scholarship. S.P.G. was supported by an Early Career Research Fellowship, Cancer Institute NSW (2011-2013). The remaining authors have no financial relationships relevant to this article to disclose.