Arterial elasticity in obese adolescents with clinical features of insulin resistance
Mandy Ho, Paul Z Benitez-Aguirre, Kim C Donaghue, Paul Mitchell, Louise A Baur, Alicia J Jenkins, Maria E Craig, Chris T Cowell, Sarah P Garnett
DIABETES & VASCULAR DISEASE RESEARCH | SAGE PUBLICATIONS LTD | Published : 2015
OBJECTIVE: To determine whether arterial elasticity differs between obese adolescents with clinical insulin resistance (IR), type 1 diabetes (T1D) and healthy non-obese controls. METHODS: This cross-sectional study evaluated 69 adolescents with clinical IR, 91 with T1D and 63 age-matched (10- to 18-year-old) controls. Arterial elasticity was measured using radial tonometry pulse-wave analysis. Stepwise multiple regression analyses were performed to assess the determinants of the small and large arterial elasticity indices (SAEI and LAEI). RESULTS: SAEI and LAEI raw values were higher in the IR group than the controls, and these did not differ between the T1D and control groups. Weight and di..View full abstract
The RESIST study was funded by BUPA Foundation Australia Pty Limited (2008-2012), Diabetes Australia Research Trust (DART, 2008) and Heart Foundation, Australia (2009-2010). M.H. is supported by a National Health and Medical Research Council (NHMRC) Australian Dora Lush Postgraduate Research Scholarship. S.P.G. was supported by an Early Career Research Fellowship, Cancer Institute NSW (2011-2013). The remaining authors have no financial relationships relevant to this article to disclose.