Increased gastrin gene expression provides a physiological advantage to mice under hypoxic conditions
Marie Laval, Graham S Baldwin, Arthur Shulkes, Kathryn M Marshall
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY | AMER PHYSIOLOGICAL SOC | Published : 2015
Hypoxia, or a low concentration of O2, is encountered in humans undertaking activities such as mountain climbing and scuba diving and is important pathophysiologically as a limiting factor in tumor growth. Although data on the interplay between hypoxia and gastrins are limited, gastrin expression is upregulated by hypoxia in gastrointestinal cancer cell lines, and gastrins counterbalance hypoxia by stimulating angiogenesis in vitro and in vivo. The aim of this study was to determine if higher concentrations of the gastrin precursor progastrin are protective against hypoxia in vivo. hGAS mice, which overexpress progastrin in the liver, and mice of the corresponding wild-type FVB/N strain were..View full abstract
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Awarded by Australian National Health and Medical Research Council
This work was supported by Australian National Health and Medical Research Council Grants 1062173 (A. Shulkes and G. S. Baldwin) and 1020983 (G. S. Baldwin).