Journal article
Omega-1 knockdown in Schistosoma mansoni eggs by lentivirus transduction reduces granuloma size in vivo
J Hagen, ND Young, AL Every, CN Pagel, C Schnoeller, JPY Scheerlinck, RB Gasser, BH Kalinna
Nature Communications | Published : 2014
DOI: 10.1038/ncomms6375
Abstract
Schistosomiasis, one of the most important neglected tropical diseases worldwide, is caused by flatworms (blood flukes or schistosomes) that live in the bloodstream of humans. The hepatointestinal form of this debilitating disease results from a chronic infection with Schistosoma mansoni or Schistosoma japonicum. No vaccine is available to prevent schistosomiasis, and treatment relies predominantly on the use of a single drug, praziquantel. In spite of considerable research effort over the years, very little is known about the complex in vivo events that lead to granuloma formation and other pathological changes during infection. Here we use, for the first time, a lentivirus-based transducti..
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Awarded by Australian Research Council
Funding Acknowledgements
Funding from the National Health and Medical Research Council (NHMRC) and the Australian Research Council (ARC) is gratefully acknowledged. This project was also partially supported by a Victorian Life Sciences Computation Initiative (VLSCI; grant number VR0007) on its Peak Computing Facility at the University of Melbourne, an initiative of the Victorian Government. We thank Dr Ross Dickins (Walter and Eliza Hall Institute of Medical Research) for discussion and support to J. H. early in her study. J. H. was the recipient of MIRS and MIFRS scholarships from the University of Melbourne. N. D. Y. is an NHMRC Early Career Research Fellow (ECRF).