Journal article
New research tools for urogenital schistosomiasis
G Rinaldi, ND Young, JD Honeycutt, PJ Brindley, RB Gasser, MH Hsieh
Journal of Infectious Diseases | Published : 2015
Abstract
Approximately 200 000 000 people have schistosomiasis (schistosome infection). Among the schistosomes, Schistosoma haematobium is responsible for the most infections, which are present in 110 million people globally, mostly in sub-Saharan Africa. This pathogen causes an astonishing breadth of sequelae: hematuria, anemia, dysuria, stunting, uremia, bladder cancer, urosepsis, and human immunodeficiency virus coinfection. Refined estimates of the impact of schistosomiasis on quality of life suggest that it rivals malaria. Despite S. haematobium's importance, relevant research has lagged. Here, we review advances that will deepen knowledge of S. haematobium. Three sets of breakthroughs will acce..
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Awarded by National Institute of Allergy and Infectious Diseases
Funding Acknowledgements
This work was supported by the National Institute of Allergy and Infectious Diseases (awards R21 AI109532 [to G. R.] and R01AI072773 [to P. J. B.]) and the National Institute of Diabetes and Digestive and Kidney Diseases (award K08 DK087895 to M. H.), National Institutes of Health; the National Health and Medical Research Council of Australia (to R. B. G. N. D. Y.); the Australian Research Council (to R. B. G.); the Alexander von Humboldt Foundation; the Victorian Life Sciences Computation Initiative (grant VR0007, on its Peak Computing Facility, University of Melbourne, an initiative of the Victorian government); and the Australian National Health and Medical Research Council (fellowship to N. D. Y.).