Journal article
Flicker light-induced retinal vasodilation is unaffected by inhibition of epoxyeicosatrienoic acids and prostaglandins in humans
JE Noonan, GJ Dusting, TT Nguyen, AJ Jenkins, REK Man, WJ Best, DA Dias, NS Jayasinghe, U Roessner, EL Lamoureux
Investigative Ophthalmology Visual Science | ASSOC RESEARCH VISION OPHTHALMOLOGY INC | Published : 2014
Abstract
PURPOSE: To investigate the role of epoxyeicosatrienoic acids (EETs) and prostaglandins (PGs) in retinal blood vessel calibers and vasodilation during flicker light stimulation in humans.METHODS: Twelve healthy nonsmokers participated in a balanced crossover study. Oral fluconazole 400 mg and dispersible aspirin 600 mg were used to inhibit production of EETs and PGs, respectively. Retinal imaging was performed 1 hour after drug ingestion with the Dynamic Vessel Analyzer. Resting calibers of selected vessel segments were recorded in measurement units (MU). Maximum percentage dilations during flicker stimulation were calculated from baseline calibers. We then studied six participants each afte..
View full abstractGrants
Awarded by Australian National Health and Medical Research Council Postgraduate Medical Scholarship
Awarded by Australian National Health and Medical Research Council Research Fellowships
Funding Acknowledgements
Supported by the Royal Victorian Eye and Ear Hospital. The Centre for Eye Research Australia receives Operational Infrastructure Support from the Victorian government. Also supported by the Australian National Health and Medical Research Council Postgraduate Medical Scholarship (ID1038701) (JEN) and Australian National Health and Medical Research Council Research Fellowships (ID1045280 and 1003113) (ELL and GJD).