BRAIN-DERIVED NEUROTROPHIC FACTOR HETEROZYGOUS MUTANT RATS SHOW SELECTIVE COGNITIVE CHANGES AND VULNERABILITY TO CHRONIC CORTICOSTERONE TREATMENT
A Gururajan, RA Hill, M van den Buuse
Neuroscience | PERGAMON-ELSEVIER SCIENCE LTD | Published : 2015
Brain-derived neurotrophic factor (BDNF) is a widely expressed neurotrophin involved in neurodevelopment, neuroprotection and synaptic plasticity. It is also implicated in a range of psychiatric disorders such as schizophrenia, depression and post-traumatic stress disorder. Stress during adolescence/young adulthood can have long-term psychiatric and cognitive consequences, however it is unknown how altered BDNF signaling is involved in such effects. Here we investigated whether a congenital deficit in BDNF availability in rats increases vulnerability to the long-term effects of the stress hormone, corticosterone (CORT). Compared to wildtype (WT) littermates, BDNF heterozygous (HET) rats show..View full abstract
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Awarded by National Health and Medical Research Council of Australia (NHMRC)
This work was supported by a National Health and Medical Research Council of Australia (NHMRC) project grant 566879 to MvdB, a postdoctoral training fellowship to RH and a senior research fellowship 509156 to MvdB. Additional support was obtained by way of operational infrastructure funding from the Victorian State Government. These funding sources had no role in the study's design, the collection, analysis and interpretation of the data, the writing of the report, or the decision to submit the article for publication.