Journal article
Effect of coadministered fat on the tolerability, safety, and pharmacokinetic properties of dihydroartemisinin-piperaquine in Papua New Guinean children with uncomplicated malaria
BR Moore, JM Benjamin, S Salman, S Griffin, E Ginny, M Page-Sharp, LJ Robinson, P Siba, KT Batty, I Mueller, TME Davis
Antimicrobial agents and chemotherapy | Published : 2014
DOI: 10.1128/AAC.03314-14
Abstract
Copyright © 2014, American Society for Microbiology. All Rights Reserved.Coadministration of dihydroartemisinin-piperaquine (DHA-PQ) with fat may improve bioavailability and antimalarial efficacy, but it might also increase toxicity. There have been no studies of these potential effects in the pediatric age group. The tolerability, safety, efficacy, and pharmacokinetics of DHA-PQ administered with or without 8.5 g fat were investigated in 30 Papua New Guinean children aged 5 to 10 years diagnosed with uncomplicated falciparum malaria. Three daily 2.5:11.5-mg-base/kg doses were given with water (n = 14, group A) or milk (n = 16, group B), with regular clinical/laboratory assessment and blood ..
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Awarded by National Health and Medical Research Council (NHMRC) of Australia
Awarded by NHMRC
Awarded by National Health and Medical Research Council of Australia
Funding Acknowledgements
The study was funded by the National Health and Medical Research Council (NHMRC) of Australia (project grant 634343). B.R.M. was supported by an NHMRC Early Career Fellowship (1036951), L.J.R. was supported by an NHMRC Early Career Fellowship (1016443), I.M. was supported by an NHMRC Senior Research Fellowship (1043345), and T.M.E.D. was supported by an NHMRC Practitioner Fellowship (572561 and 1058260).